Research progress of liver injury induced by Polygoni Mulitiflori Radix / 中国中药杂志

Polygoni Mulitiflori Radix, or dried root tuber of Polygonum multiflorum(PM), is a traditional Chinese tonic medicine, with the effect in nourishing liver and kidney, and benefiting blood essence and hair. It is widely used in clinical and healthcare products. In recent years, more and more reports about adverse reactions of root tuber of P.multiflorum and its preparations have been reported. Fortunately, there is also substantial progress in the experimental study on liver injury induced by PM. According to the literature review, the possible causes of liver injury were found to be the mixture of raw and processed PM and long-term high-dose administration. In addition, the liver injury induced by PM is idiosyncratic liver injury, and individual factors are also the important cause. At the same time, according to the literature reports, the effects of chemical components in different pathological animal models were summarized, finding that 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside was the main component for liver injury; based on the clinical manifestations of liver injury induced by PM, the effects of some chemical components on bilirubin and bile acid metabolism were analyzed. This paper reviews the study progress of liver injury induced by PM.

Retrospective Review of the Efficacy of Acupuncture Based on Clinical Reports. (1). Introduction of the Meta-analytic Method / 全日本鍼灸学会雑誌

The meta-analytic method including a criteria-based assessment and a uniformly defined effective rate of clinical studies was used to study the clinical effect of acupuncture. This method of analysis can be used for a clinical study including case-series study. A criteria-based assessment may reveal the generality and lack of bias in a clinical study and the uniformly defined effective rate represents the general effectiveness led by the study.<BR>We tried to analyze the clinical effect of acupuncture on migraine headache. As a result of analyzing to 16 reports of acupuncture treatment for migraine headache, the criteria-based assessments were widely distributed from 3 to 17 out of 20 points. In its distribution, the 4 reports designed by the randomized controlled trial scored 13, 16, 16 and 17 points, those of 2 prospective clinical studies scored 10 and 17 points, and those of 10 case-studies all scored less than 13 points.<BR>As for the uniformly defined effective rate (%) in clinical studies, the average of the reports was 77.8% (its 95% confidence interval ranged from 68.2-86.0 %) and was much higher than the placebo effective rate of mock TENS (30-35%).<BR>Considering the result of 4 randomized controlled trials, this meta-analytic result suggests the high efficacy of acupuncture in the treatment of migraine headache.